RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
miR-21-5p
RNA ID
MIMAT0000076
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
Exoscreen assay; MicroRNA PCR array in mouse serum EVS; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
27596748
Title
Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis
Year
2016
Function
"Serum EV miR-21-5p was elevated in both the acute inflammatory phase (day 7) and the chronic fibrotic phase (day 28) in the mouse model.Serum EV miR-21-5p was significantly higher in IPF patients than in healthy control subjects. The baseline serum EV miR-21-5p was correlated with the rate of decline in vital capacity over 6 months. Furthermore, serum EV miR-21-5p was independently associated with mortality during the following 30 months, even after adjustment for other variables. In the survival analysis, IPF patients whose baseline serum EV miR-21-5p was high had a significantly poorer prognosis over 30 months. Serum EV miR-21-5p has potential as a prognostic biomarker for IPF."